[data] 文献 1792 篇｜2015–2019 606 篇｜2020–2026 1186 篇
[data] 至少出现在 20 篇里的 MeSH 词: 115 个
[实测] FDR<0.05 的主题词: 55 个
[零模型] 1000 次打乱：均值 0.04｜95分位 0.0｜最大 5
[H1] 55 > 0.0 且 >=5 → ✅成立

  升幅最大：
    Hyperthermic Intraperitoneal Chemotherapy        0.0% →  29.1%  (FDR 4.6e-69)
    Colorectal Neoplasms                            68.2% →  76.4%  (FDR 7.7e-04)
    Retrospective Studies                           26.6% →  32.4%  (FDR 2.9e-02)
    Mice                                             6.1% →  10.0%  (FDR 1.6e-02)
    Tumor Microenvironment                           0.8% →   4.5%  (FDR 3.8e-05)
    Immunotherapy                                    0.2% →   2.3%  (FDR 6.3e-04)
  降幅最大：
    Male                                            65.0% →  38.8%  (FDR 3.7e-24)
    Middle Aged                                     55.8% →  35.3%  (FDR 4.3e-15)
    Female                                          66.3% →  46.0%  (FDR 5.0e-15)
    Aged                                            49.3% →  33.2%  (FDR 5.4e-10)
    Adult                                           33.8% →  23.0%  (FDR 8.2e-06)
    Young Adult                                     13.5% →   2.9%  (FDR 2.4e-15)

[H2] 升幅词里含免疫/单细胞/靶向类新兴主题 → ✅成立｜命中 ['Tumor Microenvironment', 'Immunotherapy']