=== run started 2026-08-07T17:30:52Z === [ 0.0s] === FETCH PHASE === [ 70.6s] fetch_self(H7_MYOPIA) done in 70.6s -> hits=1167 scaffold=283340 [ 70.6s] SINGLE_SHOT=1 -> stopping after this fetch so the caller can invoke the next stage [ 0.0s] === FETCH PHASE === [ 0.0s] fetch_self(H7_MYOPIA) SKIP (already done): hits=1167 scaffold=283340 [ 0.2s] target_scaffold built: 283340 positions [ 70.3s] fetch_lookup(M13_RHEUMA) done in 70.1s -> join=283340 hits=34451 [ 70.3s] SINGLE_SHOT=1 -> stopping after this fetch so the caller can invoke the next stage [ 0.0s] === FETCH PHASE === [ 0.0s] fetch_self(H7_MYOPIA) SKIP (already done): hits=1167 scaffold=283340 [ 0.2s] target_scaffold built: 283340 positions [ 0.2s] fetch_lookup(M13_RHEUMA) SKIP (already done): join=283340 hits=34451 [ 70.2s] fetch_lookup(SPONDYLOARTHRITIS) done in 70.0s -> join=283340 hits=38211 [ 70.2s] SINGLE_SHOT=1 -> stopping after this fetch so the caller can invoke the next stage [ 0.0s] === FETCH PHASE === [ 0.0s] fetch_self(H7_MYOPIA) SKIP (already done): hits=1167 scaffold=283340 [ 0.2s] target_scaffold built: 283340 positions [ 0.2s] fetch_lookup(M13_RHEUMA) SKIP (already done): join=283340 hits=34451 [ 0.3s] fetch_lookup(SPONDYLOARTHRITIS) SKIP (already done): join=283340 hits=38211 [ 69.8s] fetch_lookup(M13_PSORIARTH) done in 69.5s -> join=283340 hits=19777 [ 69.8s] SINGLE_SHOT=1 -> stopping after this fetch so the caller can invoke the next stage [ 0.0s] === FETCH PHASE === [ 0.0s] fetch_self(H7_MYOPIA) SKIP (already done): hits=1167 scaffold=283340 [ 0.2s] target_scaffold built: 283340 positions [ 0.2s] fetch_lookup(M13_RHEUMA) SKIP (already done): join=283340 hits=34451 [ 0.3s] fetch_lookup(SPONDYLOARTHRITIS) SKIP (already done): join=283340 hits=38211 [ 0.3s] fetch_lookup(M13_PSORIARTH) SKIP (already done): join=283340 hits=19777 [ 71.0s] fetch_lookup(CD2_BENIGN_LEIOMYOMA_UTERI) done in 70.7s -> join=283340 hits=26419 [ 71.0s] SINGLE_SHOT=1 -> stopping after this fetch so the caller can invoke the next stage [ 0.0s] === FETCH PHASE === [ 0.0s] fetch_self(H7_MYOPIA) SKIP (already done): hits=1167 scaffold=283340 [ 0.2s] target_scaffold built: 283340 positions [ 0.3s] fetch_lookup(M13_RHEUMA) SKIP (already done): join=283340 hits=34451 [ 0.3s] fetch_lookup(SPONDYLOARTHRITIS) SKIP (already done): join=283340 hits=38211 [ 0.3s] fetch_lookup(M13_PSORIARTH) SKIP (already done): join=283340 hits=19777 [ 0.4s] fetch_lookup(CD2_BENIGN_LEIOMYOMA_UTERI) SKIP (already done): join=283340 hits=26419 [ 0.4s] === CLUMP ANCHOR LEAD SNPS === [ 0.7s] anchor myopia (H7_MYOPIA): 1167 hits(p<1e-05) -> 7 clumped lead SNPs (p<5e-08) [ 0.8s] anchor rheuma (M13_RHEUMA): 34451 hits(p<1e-05) -> 41 clumped lead SNPs (p<5e-08) [ 0.9s] anchor spondylo (SPONDYLOARTHRITIS): 38211 hits(p<1e-05) -> 13 clumped lead SNPs (p<5e-08) [ 0.9s] anchor psoriarth (M13_PSORIARTH): 19777 hits(p<1e-05) -> 15 clumped lead SNPs (p<5e-08) [ 1.3s] anchor leiomyoma (CD2_BENIGN_LEIOMYOMA_UTERI): 26419 hits(p<1e-05) -> 111 clumped lead SNPs (p<5e-08) [ 1.3s] union of lead SNP keys across 5 anchor-role traits: 186 [ 1.4s] target_combined built: 283522 positions (scaffold 283340 + leadsnp-only 182) [ 72.4s] fetch_lookup(N14_ENDOMETRIOSIS) done in 71.0s -> join=283522 hits=0 [ 72.4s] SINGLE_SHOT=1 -> stopping after this fetch so the caller can invoke the next stage [ 0.0s] === FETCH PHASE === [ 0.0s] fetch_self(H7_MYOPIA) SKIP (already done): hits=1167 scaffold=283340 [ 0.2s] target_scaffold built: 283340 positions [ 0.2s] fetch_lookup(M13_RHEUMA) SKIP (already done): join=283340 hits=34451 [ 0.3s] fetch_lookup(SPONDYLOARTHRITIS) SKIP (already done): join=283340 hits=38211 [ 0.3s] fetch_lookup(M13_PSORIARTH) SKIP (already done): join=283340 hits=19777 [ 0.3s] fetch_lookup(CD2_BENIGN_LEIOMYOMA_UTERI) SKIP (already done): join=283340 hits=26419 [ 0.3s] === CLUMP ANCHOR LEAD SNPS === [ 0.6s] anchor myopia (H7_MYOPIA): 1167 hits(p<1e-05) -> 7 clumped lead SNPs (p<5e-08) [ 0.6s] anchor rheuma (M13_RHEUMA): 34451 hits(p<1e-05) -> 41 clumped lead SNPs (p<5e-08) [ 0.7s] anchor spondylo (SPONDYLOARTHRITIS): 38211 hits(p<1e-05) -> 13 clumped lead SNPs (p<5e-08) [ 0.7s] anchor psoriarth (M13_PSORIARTH): 19777 hits(p<1e-05) -> 15 clumped lead SNPs (p<5e-08) [ 1.1s] anchor leiomyoma (CD2_BENIGN_LEIOMYOMA_UTERI): 26419 hits(p<1e-05) -> 111 clumped lead SNPs (p<5e-08) [ 1.1s] union of lead SNP keys across 5 anchor-role traits: 186 [ 1.2s] target_combined built: 283522 positions (scaffold 283340 + leadsnp-only 182) [ 1.2s] fetch_lookup(N14_ENDOMETRIOSIS) SKIP (already done): join=283522 hits=0 [ 70.2s] fetch_lookup(N14_ENDOMETRIOSIS_OVARY) done in 69.0s -> join=283522 hits=0 [ 70.2s] SINGLE_SHOT=1 -> stopping after this fetch so the caller can invoke the next stage [ 1.3s] target_combined built: 283522 positions (scaffold 283340 + leadsnp-only 182) [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS) SKIP (already done): join=283522 hits=0 [ 1.4s] fetch_lookup(N14_ENDOMETRIOSIS_OVARY) SKIP (already done): join=283522 hits=0 [ 70.9s] fetch_lookup(N14_ENDOMETRIOSIS_PELVICPERITONEUM) done in 69.6s -> join=283522 hits=0 [ 70.9s] SINGLE_SHOT=1 -> stopping after this fetch so the caller can invoke the next stage [ 1.2s] fetch_lookup(N14_ENDOMETRIOSIS) SKIP (already done): join=283522 hits=0 [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS_OVARY) SKIP (already done): join=283522 hits=0 [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS_PELVICPERITONEUM) SKIP (already done): join=283522 hits=0 [ 72.7s] fetch_lookup(N14_ENDOMETRIOSIS_UTERUS) done in 71.4s -> join=283522 hits=0 [ 72.7s] SINGLE_SHOT=1 -> stopping after this fetch so the caller can invoke the next stage [ 1.2s] fetch_lookup(N14_ENDOMETRIOSIS_OVARY) SKIP (already done): join=283522 hits=0 [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS_PELVICPERITONEUM) SKIP (already done): join=283522 hits=0 [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS_UTERUS) SKIP (already done): join=283522 hits=0 [ 70.3s] fetch_lookup(N14_ENDOMETRIOSIS_RECTPVAGSEPT_VAGINA) done in 69.0s -> join=283522 hits=0 [ 70.3s] SINGLE_SHOT=1 -> stopping after this fetch so the caller can invoke the next stage [ 0.0s] === FETCH PHASE === [ 0.0s] fetch_self(H7_MYOPIA) SKIP (already done): hits=1167 scaffold=283340 [ 0.2s] target_scaffold built: 283340 positions [ 0.2s] fetch_lookup(M13_RHEUMA) SKIP (already done): join=283340 hits=34451 [ 0.3s] fetch_lookup(SPONDYLOARTHRITIS) SKIP (already done): join=283340 hits=38211 [ 0.3s] fetch_lookup(M13_PSORIARTH) SKIP (already done): join=283340 hits=19777 [ 0.3s] fetch_lookup(CD2_BENIGN_LEIOMYOMA_UTERI) SKIP (already done): join=283340 hits=26419 [ 0.3s] === CLUMP ANCHOR LEAD SNPS === [ 0.6s] anchor myopia (H7_MYOPIA): 1167 hits(p<1e-05) -> 7 clumped lead SNPs (p<5e-08) [ 0.6s] anchor rheuma (M13_RHEUMA): 34451 hits(p<1e-05) -> 41 clumped lead SNPs (p<5e-08) [ 0.7s] anchor spondylo (SPONDYLOARTHRITIS): 38211 hits(p<1e-05) -> 13 clumped lead SNPs (p<5e-08) [ 0.7s] anchor psoriarth (M13_PSORIARTH): 19777 hits(p<1e-05) -> 15 clumped lead SNPs (p<5e-08) [ 1.1s] anchor leiomyoma (CD2_BENIGN_LEIOMYOMA_UTERI): 26419 hits(p<1e-05) -> 111 clumped lead SNPs (p<5e-08) [ 1.1s] union of lead SNP keys across 5 anchor-role traits: 186 [ 1.2s] target_combined built: 283522 positions (scaffold 283340 + leadsnp-only 182) [ 1.2s] fetch_lookup(N14_ENDOMETRIOSIS) SKIP (already done): join=283522 hits=0 [ 1.2s] fetch_lookup(N14_ENDOMETRIOSIS_OVARY) SKIP (already done): join=283522 hits=0 [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS_PELVICPERITONEUM) SKIP (already done): join=283522 hits=0 [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS_UTERUS) SKIP (already done): join=283522 hits=0 [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS_RECTPVAGSEPT_VAGINA) SKIP (already done): join=283522 hits=0 [ 1.3s] === FETCH PHASE DONE at 1.3s === [ 1.3s] === LOAD JOINED TABLES === [ 7.1s] scaffold retention fractions: {'rheuma': 1.0, 'spondylo': 1.0, 'psoriarth': 1.0, 'leiomyoma': 1.0, 'myopia': 1.0, 'pooled': 1.0006, 'ovary': 1.0006, 'pelvicperitoneum': 1.0006, 'uterus': 1.0006, 'rectovaginal': 1.0006} [ 7.1s] === OBSERVED STATISTICS (all anchor x endo-trait pairs) === [ 7.1s] anchor=myopia endo=pooled n= 7 sign_conc=0.571 ivw_slope=-0.000 [ 7.2s] anchor=myopia endo=ovary n= 7 sign_conc=0.286 ivw_slope=-0.035 [ 7.2s] anchor=myopia endo=pelvicperitoneum n= 7 sign_conc=0.429 ivw_slope=0.009 [ 7.2s] anchor=myopia endo=uterus n= 7 sign_conc=0.429 ivw_slope=-0.041 [ 7.2s] anchor=myopia endo=rectovaginal n= 7 sign_conc=0.286 ivw_slope=-0.022 [ 7.3s] anchor=rheuma endo=pooled n= 41 sign_conc=0.463 ivw_slope=-0.024 [ 7.3s] anchor=rheuma endo=ovary n= 41 sign_conc=0.439 ivw_slope=-0.074 [ 7.4s] anchor=rheuma endo=pelvicperitoneum n= 41 sign_conc=0.463 ivw_slope=-0.032 [ 7.4s] anchor=rheuma endo=uterus n= 41 sign_conc=0.659 ivw_slope=0.054 [ 7.4s] anchor=rheuma endo=rectovaginal n= 41 sign_conc=0.512 ivw_slope=-0.030 [ 7.4s] anchor=spondylo endo=pooled n= 13 sign_conc=0.769 ivw_slope=0.045 [ 7.5s] anchor=spondylo endo=ovary n= 13 sign_conc=0.692 ivw_slope=0.038 [ 7.5s] anchor=spondylo endo=pelvicperitoneum n= 13 sign_conc=0.615 ivw_slope=0.070 [ 7.5s] anchor=spondylo endo=uterus n= 13 sign_conc=0.615 ivw_slope=0.016 [ 7.6s] anchor=spondylo endo=rectovaginal n= 13 sign_conc=0.692 ivw_slope=0.054 [ 7.6s] anchor=psoriarth endo=pooled n= 15 sign_conc=0.333 ivw_slope=-0.036 [ 7.6s] anchor=psoriarth endo=ovary n= 15 sign_conc=0.200 ivw_slope=-0.071 [ 7.7s] anchor=psoriarth endo=pelvicperitoneum n= 15 sign_conc=0.067 ivw_slope=-0.094 [ 7.7s] anchor=psoriarth endo=uterus n= 15 sign_conc=0.467 ivw_slope=-0.017 [ 7.7s] anchor=psoriarth endo=rectovaginal n= 15 sign_conc=0.600 ivw_slope=0.007 [ 7.8s] anchor=leiomyoma endo=pooled n=111 sign_conc=0.811 ivw_slope=0.302 [ 7.8s] anchor=leiomyoma endo=ovary n=111 sign_conc=0.757 ivw_slope=0.343 [ 7.8s] anchor=leiomyoma endo=pelvicperitoneum n=111 sign_conc=0.730 ivw_slope=0.269 [ 7.9s] anchor=leiomyoma endo=uterus n=111 sign_conc=0.757 ivw_slope=0.317 [ 7.9s] anchor=leiomyoma endo=rectovaginal n=111 sign_conc=0.739 ivw_slope=0.371 [ 7.9s] === NULL DISTRIBUTIONS (MAF-matched, distance-excluded) === [ 8.2s] null anchor=myopia endo=pooled pool=282032 p_sign_conc(seeds)=[np.float64(0.5035), np.float64(0.5125), np.float64(0.5285)] [ 8.4s] null anchor=myopia endo=ovary pool=282032 p_sign_conc(seeds)=[np.float64(0.9441), np.float64(0.9451), np.float64(0.9371)] [ 8.5s] null anchor=myopia endo=pelvicperitoneum pool=282032 p_sign_conc(seeds)=[np.float64(0.7902), np.float64(0.7952), np.float64(0.7862)] [ 8.7s] null anchor=myopia endo=uterus pool=282032 p_sign_conc(seeds)=[np.float64(0.7742), np.float64(0.7922), np.float64(0.7872)] [ 8.8s] null anchor=myopia endo=rectovaginal pool=282032 p_sign_conc(seeds)=[np.float64(0.9341), np.float64(0.9421), np.float64(0.9401)] [ 9.2s] null anchor=rheuma endo=pooled pool=275779 p_sign_conc(seeds)=[np.float64(0.7842), np.float64(0.8022), np.float64(0.8012)] [ 9.4s] null anchor=rheuma endo=ovary pool=275779 p_sign_conc(seeds)=[np.float64(0.8402), np.float64(0.8521), np.float64(0.8681)] [ 9.7s] null anchor=rheuma endo=pelvicperitoneum pool=275779 p_sign_conc(seeds)=[np.float64(0.7433), np.float64(0.7762), np.float64(0.7782)] [ 9.9s] null anchor=rheuma endo=uterus pool=275779 p_sign_conc(seeds)=[np.float64(0.046), np.float64(0.029), np.float64(0.045)] [ 10.1s] null anchor=rheuma endo=rectovaginal pool=275779 p_sign_conc(seeds)=[np.float64(0.5664), np.float64(0.5495), np.float64(0.5574)] [ 10.4s] null anchor=spondylo endo=pooled pool=281215 p_sign_conc(seeds)=[np.float64(0.0529), np.float64(0.0559), np.float64(0.05)] [ 10.6s] null anchor=spondylo endo=ovary pool=281215 p_sign_conc(seeds)=[np.float64(0.1339), np.float64(0.1558), np.float64(0.1499)] [ 10.7s] null anchor=spondylo endo=pelvicperitoneum pool=281215 p_sign_conc(seeds)=[np.float64(0.3427), np.float64(0.3087), np.float64(0.3077)] [ 10.9s] null anchor=spondylo endo=uterus pool=281215 p_sign_conc(seeds)=[np.float64(0.3027), np.float64(0.2977), np.float64(0.2787)] [ 11.0s] null anchor=spondylo endo=rectovaginal pool=281215 p_sign_conc(seeds)=[np.float64(0.1259), np.float64(0.1449), np.float64(0.1399)] [ 11.3s] null anchor=psoriarth endo=pooled pool=280348 p_sign_conc(seeds)=[np.float64(0.954), np.float64(0.951), np.float64(0.955)] [ 11.5s] null anchor=psoriarth endo=ovary pool=280348 p_sign_conc(seeds)=[np.float64(0.998), np.float64(0.994), np.float64(0.993)] [ 11.7s] null anchor=psoriarth endo=pelvicperitoneum pool=280348 p_sign_conc(seeds)=[np.float64(1.0), np.float64(1.0), np.float64(1.0)] [ 11.8s] null anchor=psoriarth endo=uterus pool=280348 p_sign_conc(seeds)=[np.float64(0.7183), np.float64(0.6993), np.float64(0.7243)] [ 12.0s] null anchor=psoriarth endo=rectovaginal pool=280348 p_sign_conc(seeds)=[np.float64(0.3087), np.float64(0.3247), np.float64(0.3157)] [ 12.6s] null anchor=leiomyoma endo=pooled pool=263233 p_sign_conc(seeds)=[np.float64(0.001), np.float64(0.001), np.float64(0.001)] [ 13.0s] null anchor=leiomyoma endo=ovary pool=263233 p_sign_conc(seeds)=[np.float64(0.001), np.float64(0.001), np.float64(0.001)] [ 13.4s] null anchor=leiomyoma endo=pelvicperitoneum pool=263233 p_sign_conc(seeds)=[np.float64(0.001), np.float64(0.001), np.float64(0.001)] [ 13.8s] null anchor=leiomyoma endo=uterus pool=263233 p_sign_conc(seeds)=[np.float64(0.001), np.float64(0.001), np.float64(0.001)] [ 14.2s] null anchor=leiomyoma endo=rectovaginal pool=263233 p_sign_conc(seeds)=[np.float64(0.001), np.float64(0.001), np.float64(0.001)] [ 14.2s] === DELTA vs POOLED (paired locus bootstrap) === [ 14.3s] delta anchor=rheuma site=ovary n= 41 obs_delta_sign=-0.024 CI=[-0.171,+0.122] covers0=True [ 14.4s] delta anchor=rheuma site=pelvicperitoneum n= 41 obs_delta_sign=+0.000 CI=[-0.146,+0.146] covers0=True [ 14.4s] delta anchor=rheuma site=uterus n= 41 obs_delta_sign=+0.195 CI=[+0.024,+0.366] covers0=False [ 14.5s] delta anchor=rheuma site=rectovaginal n= 41 obs_delta_sign=+0.049 CI=[-0.122,+0.220] covers0=True [ 14.6s] delta anchor=spondylo site=ovary n= 13 obs_delta_sign=-0.077 CI=[-0.308,+0.154] covers0=True [ 14.7s] delta anchor=spondylo site=pelvicperitoneum n= 13 obs_delta_sign=-0.154 CI=[-0.385,+0.000] covers0=True [ 14.7s] delta anchor=spondylo site=uterus n= 13 obs_delta_sign=-0.154 CI=[-0.385,+0.000] covers0=True [ 14.8s] delta anchor=spondylo site=rectovaginal n= 13 obs_delta_sign=-0.077 CI=[-0.385,+0.231] covers0=True [ 14.9s] delta anchor=psoriarth site=ovary n= 15 obs_delta_sign=-0.133 CI=[-0.333,+0.000] covers0=True [ 15.0s] delta anchor=psoriarth site=pelvicperitoneum n= 15 obs_delta_sign=-0.267 CI=[-0.467,-0.067] covers0=False [ 15.0s] delta anchor=psoriarth site=uterus n= 15 obs_delta_sign=+0.133 CI=[+0.000,+0.333] covers0=True [ 15.1s] delta anchor=psoriarth site=rectovaginal n= 15 obs_delta_sign=+0.267 CI=[-0.067,+0.600] covers0=True [ 15.1s] === ASSEMBLE results.json === [ 15.4s] results.json written [ 17.2s] candidate_shared_loci.csv written (hypothesis-generating only) [ 17.6s] figure written: figs/site_specificity.png [ 17.6s] === DONE at 17.6s === === re-running analysis phase to bake in deviations 2026-08-07T17:45:20Z === [ 0.0s] === FETCH PHASE === [ 0.0s] fetch_self(H7_MYOPIA) SKIP (already done): hits=1167 scaffold=283340 [ 0.2s] target_scaffold built: 283340 positions [ 0.2s] fetch_lookup(M13_RHEUMA) SKIP (already done): join=283340 hits=34451 [ 0.3s] fetch_lookup(SPONDYLOARTHRITIS) SKIP (already done): join=283340 hits=38211 [ 0.3s] fetch_lookup(M13_PSORIARTH) SKIP (already done): join=283340 hits=19777 [ 0.3s] fetch_lookup(CD2_BENIGN_LEIOMYOMA_UTERI) SKIP (already done): join=283340 hits=26419 [ 0.3s] === CLUMP ANCHOR LEAD SNPS === [ 0.6s] anchor myopia (H7_MYOPIA): 1167 hits(p<1e-05) -> 7 clumped lead SNPs (p<5e-08) [ 0.6s] anchor rheuma (M13_RHEUMA): 34451 hits(p<1e-05) -> 41 clumped lead SNPs (p<5e-08) [ 0.7s] anchor spondylo (SPONDYLOARTHRITIS): 38211 hits(p<1e-05) -> 13 clumped lead SNPs (p<5e-08) [ 0.7s] anchor psoriarth (M13_PSORIARTH): 19777 hits(p<1e-05) -> 15 clumped lead SNPs (p<5e-08) [ 1.1s] anchor leiomyoma (CD2_BENIGN_LEIOMYOMA_UTERI): 26419 hits(p<1e-05) -> 111 clumped lead SNPs (p<5e-08) [ 1.1s] union of lead SNP keys across 5 anchor-role traits: 186 [ 1.2s] target_combined built: 283522 positions (scaffold 283340 + leadsnp-only 182) [ 1.2s] fetch_lookup(N14_ENDOMETRIOSIS) SKIP (already done): join=283522 hits=0 [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS_OVARY) SKIP (already done): join=283522 hits=0 [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS_PELVICPERITONEUM) SKIP (already done): join=283522 hits=0 [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS_UTERUS) SKIP (already done): join=283522 hits=0 [ 1.3s] fetch_lookup(N14_ENDOMETRIOSIS_RECTPVAGSEPT_VAGINA) SKIP (already done): join=283522 hits=0 [ 1.3s] === FETCH PHASE DONE at 1.3s === [ 1.3s] === LOAD JOINED TABLES === [ 7.1s] scaffold retention fractions: {'rheuma': 1.0, 'spondylo': 1.0, 'psoriarth': 1.0, 'leiomyoma': 1.0, 'myopia': 1.0, 'pooled': 1.0006, 'ovary': 1.0006, 'pelvicperitoneum': 1.0006, 'uterus': 1.0006, 'rectovaginal': 1.0006} [ 7.1s] === OBSERVED STATISTICS (all anchor x endo-trait pairs) === [ 7.1s] anchor=myopia endo=pooled n= 7 sign_conc=0.571 ivw_slope=-0.000 [ 7.2s] anchor=myopia endo=ovary n= 7 sign_conc=0.286 ivw_slope=-0.035 [ 7.2s] anchor=myopia endo=pelvicperitoneum n= 7 sign_conc=0.429 ivw_slope=0.009 [ 7.2s] anchor=myopia endo=uterus n= 7 sign_conc=0.429 ivw_slope=-0.041 [ 7.3s] anchor=myopia endo=rectovaginal n= 7 sign_conc=0.286 ivw_slope=-0.022 [ 7.3s] anchor=rheuma endo=pooled n= 41 sign_conc=0.463 ivw_slope=-0.024 [ 7.3s] anchor=rheuma endo=ovary n= 41 sign_conc=0.439 ivw_slope=-0.074 [ 7.4s] anchor=rheuma endo=pelvicperitoneum n= 41 sign_conc=0.463 ivw_slope=-0.032 [ 7.4s] anchor=rheuma endo=uterus n= 41 sign_conc=0.659 ivw_slope=0.054 [ 7.5s] anchor=rheuma endo=rectovaginal n= 41 sign_conc=0.512 ivw_slope=-0.030 [ 7.5s] anchor=spondylo endo=pooled n= 13 sign_conc=0.769 ivw_slope=0.045 [ 7.5s] anchor=spondylo endo=ovary n= 13 sign_conc=0.692 ivw_slope=0.038 [ 7.5s] anchor=spondylo endo=pelvicperitoneum n= 13 sign_conc=0.615 ivw_slope=0.070 [ 7.6s] anchor=spondylo endo=uterus n= 13 sign_conc=0.615 ivw_slope=0.016 [ 7.6s] anchor=spondylo endo=rectovaginal n= 13 sign_conc=0.692 ivw_slope=0.054 [ 7.6s] anchor=psoriarth endo=pooled n= 15 sign_conc=0.333 ivw_slope=-0.036 [ 7.7s] anchor=psoriarth endo=ovary n= 15 sign_conc=0.200 ivw_slope=-0.071 [ 7.7s] anchor=psoriarth endo=pelvicperitoneum n= 15 sign_conc=0.067 ivw_slope=-0.094 [ 7.7s] anchor=psoriarth endo=uterus n= 15 sign_conc=0.467 ivw_slope=-0.017 [ 7.8s] anchor=psoriarth endo=rectovaginal n= 15 sign_conc=0.600 ivw_slope=0.007 [ 7.8s] anchor=leiomyoma endo=pooled n=111 sign_conc=0.811 ivw_slope=0.302 [ 7.8s] anchor=leiomyoma endo=ovary n=111 sign_conc=0.757 ivw_slope=0.343 [ 7.9s] anchor=leiomyoma endo=pelvicperitoneum n=111 sign_conc=0.730 ivw_slope=0.269 [ 7.9s] anchor=leiomyoma endo=uterus n=111 sign_conc=0.757 ivw_slope=0.317 [ 7.9s] anchor=leiomyoma endo=rectovaginal n=111 sign_conc=0.739 ivw_slope=0.371 [ 7.9s] === NULL DISTRIBUTIONS (MAF-matched, distance-excluded) === [ 8.2s] null anchor=myopia endo=pooled pool=282032 p_sign_conc(seeds)=[np.float64(0.5035), np.float64(0.5125), np.float64(0.5285)] [ 8.4s] null anchor=myopia endo=ovary pool=282032 p_sign_conc(seeds)=[np.float64(0.9441), np.float64(0.9451), np.float64(0.9371)] [ 8.6s] null anchor=myopia endo=pelvicperitoneum pool=282032 p_sign_conc(seeds)=[np.float64(0.7902), np.float64(0.7952), np.float64(0.7862)] [ 8.8s] null anchor=myopia endo=uterus pool=282032 p_sign_conc(seeds)=[np.float64(0.7742), np.float64(0.7922), np.float64(0.7872)] [ 8.9s] null anchor=myopia endo=rectovaginal pool=282032 p_sign_conc(seeds)=[np.float64(0.9341), np.float64(0.9421), np.float64(0.9401)] [ 9.4s] null anchor=rheuma endo=pooled pool=275779 p_sign_conc(seeds)=[np.float64(0.7842), np.float64(0.8022), np.float64(0.8012)] [ 9.6s] null anchor=rheuma endo=ovary pool=275779 p_sign_conc(seeds)=[np.float64(0.8402), np.float64(0.8521), np.float64(0.8681)] [ 9.9s] null anchor=rheuma endo=pelvicperitoneum pool=275779 p_sign_conc(seeds)=[np.float64(0.7433), np.float64(0.7762), np.float64(0.7782)] [ 10.1s] null anchor=rheuma endo=uterus pool=275779 p_sign_conc(seeds)=[np.float64(0.046), np.float64(0.029), np.float64(0.045)] [ 10.3s] null anchor=rheuma endo=rectovaginal pool=275779 p_sign_conc(seeds)=[np.float64(0.5664), np.float64(0.5495), np.float64(0.5574)] [ 10.7s] null anchor=spondylo endo=pooled pool=281215 p_sign_conc(seeds)=[np.float64(0.0529), np.float64(0.0559), np.float64(0.05)] [ 10.8s] null anchor=spondylo endo=ovary pool=281215 p_sign_conc(seeds)=[np.float64(0.1339), np.float64(0.1558), np.float64(0.1499)] [ 11.0s] null anchor=spondylo endo=pelvicperitoneum pool=281215 p_sign_conc(seeds)=[np.float64(0.3427), np.float64(0.3087), np.float64(0.3077)] [ 11.2s] null anchor=spondylo endo=uterus pool=281215 p_sign_conc(seeds)=[np.float64(0.3027), np.float64(0.2977), np.float64(0.2787)] [ 11.4s] null anchor=spondylo endo=rectovaginal pool=281215 p_sign_conc(seeds)=[np.float64(0.1259), np.float64(0.1449), np.float64(0.1399)] [ 11.8s] null anchor=psoriarth endo=pooled pool=280348 p_sign_conc(seeds)=[np.float64(0.954), np.float64(0.951), np.float64(0.955)] [ 11.9s] null anchor=psoriarth endo=ovary pool=280348 p_sign_conc(seeds)=[np.float64(0.998), np.float64(0.994), np.float64(0.993)] [ 12.1s] null anchor=psoriarth endo=pelvicperitoneum pool=280348 p_sign_conc(seeds)=[np.float64(1.0), np.float64(1.0), np.float64(1.0)] [ 12.3s] null anchor=psoriarth endo=uterus pool=280348 p_sign_conc(seeds)=[np.float64(0.7183), np.float64(0.6993), np.float64(0.7243)] [ 12.4s] null anchor=psoriarth endo=rectovaginal pool=280348 p_sign_conc(seeds)=[np.float64(0.3087), np.float64(0.3247), np.float64(0.3157)] [ 13.1s] null anchor=leiomyoma endo=pooled pool=263233 p_sign_conc(seeds)=[np.float64(0.001), np.float64(0.001), np.float64(0.001)] [ 13.5s] null anchor=leiomyoma endo=ovary pool=263233 p_sign_conc(seeds)=[np.float64(0.001), np.float64(0.001), np.float64(0.001)] [ 14.0s] null anchor=leiomyoma endo=pelvicperitoneum pool=263233 p_sign_conc(seeds)=[np.float64(0.001), np.float64(0.001), np.float64(0.001)] [ 14.5s] null anchor=leiomyoma endo=uterus pool=263233 p_sign_conc(seeds)=[np.float64(0.001), np.float64(0.001), np.float64(0.001)] [ 14.9s] null anchor=leiomyoma endo=rectovaginal pool=263233 p_sign_conc(seeds)=[np.float64(0.001), np.float64(0.001), np.float64(0.001)] [ 14.9s] === DELTA vs POOLED (paired locus bootstrap) === [ 15.0s] delta anchor=rheuma site=ovary n= 41 obs_delta_sign=-0.024 CI=[-0.171,+0.122] covers0=True [ 15.1s] delta anchor=rheuma site=pelvicperitoneum n= 41 obs_delta_sign=+0.000 CI=[-0.146,+0.146] covers0=True [ 15.1s] delta anchor=rheuma site=uterus n= 41 obs_delta_sign=+0.195 CI=[+0.024,+0.366] covers0=False [ 15.2s] delta anchor=rheuma site=rectovaginal n= 41 obs_delta_sign=+0.049 CI=[-0.122,+0.220] covers0=True [ 15.3s] delta anchor=spondylo site=ovary n= 13 obs_delta_sign=-0.077 CI=[-0.308,+0.154] covers0=True [ 15.3s] delta anchor=spondylo site=pelvicperitoneum n= 13 obs_delta_sign=-0.154 CI=[-0.385,+0.000] covers0=True [ 15.4s] delta anchor=spondylo site=uterus n= 13 obs_delta_sign=-0.154 CI=[-0.385,+0.000] covers0=True [ 15.4s] delta anchor=spondylo site=rectovaginal n= 13 obs_delta_sign=-0.077 CI=[-0.385,+0.231] covers0=True [ 15.5s] delta anchor=psoriarth site=ovary n= 15 obs_delta_sign=-0.133 CI=[-0.333,+0.000] covers0=True [ 15.6s] delta anchor=psoriarth site=pelvicperitoneum n= 15 obs_delta_sign=-0.267 CI=[-0.467,-0.067] covers0=False [ 15.7s] delta anchor=psoriarth site=uterus n= 15 obs_delta_sign=+0.133 CI=[+0.000,+0.333] covers0=True [ 15.7s] delta anchor=psoriarth site=rectovaginal n= 15 obs_delta_sign=+0.267 CI=[-0.067,+0.600] covers0=True [ 15.7s] === ASSEMBLE results.json === [ 16.0s] results.json written [ 17.8s] candidate_shared_loci.csv written (hypothesis-generating only) [ 18.1s] figure written: figs/site_specificity.png [ 18.1s] === DONE at 18.1s ===