[10:49:55] loading CTD chem-gene interactions (human)
[10:50:08] 20 TCM compounds -> union of 9129 human target genes
[10:50:08] null pools: >=20 targets n=1972, >=50 targets n=1036
[10:50:08] loading CTD curated gene-disease (ischemic stroke MeSH set)
[10:50:08] stroke genes (union of 5 MeSH ids): 131
[10:50:08] building STRING physical-interaction adjacency at score>=400
[10:50:10]   threshold=400: 15809 genes, 421334 directed edge-records in adjacency
[10:50:10]   threshold=400: using null_reps=1000, time_remaining=986s
[10:50:42]   threshold=400 seed=0: baseline_auroc=0.6945 null_auroc_mean=0.6813 p=0.1029 n_cand=1944 (32.0s, 1000 null reps)
[10:51:11]   threshold=400 seed=1: baseline_auroc=0.7197 null_auroc_mean=0.7148 p=0.4116 n_cand=1644 (29.3s, 1000 null reps)
[10:51:39]   threshold=400 seed=2: baseline_auroc=0.6990 null_auroc_mean=0.6773 p=0.2318 n_cand=1513 (27.6s, 1000 null reps)
[10:51:39] building STRING physical-interaction adjacency at score>=700
[10:51:40]   threshold=700: 10746 genes, 173038 directed edge-records in adjacency
[10:51:40]   threshold=700: using null_reps=1000, time_remaining=895s
[10:51:51]   threshold=700 seed=0: baseline_auroc=0.5543 null_auroc_mean=0.5191 p=0.1728 n_cand=913 (11.2s, 1000 null reps)
[10:52:02]   threshold=700 seed=1: baseline_auroc=0.6742 null_auroc_mean=0.6835 p=0.6194 n_cand=870 (11.1s, 1000 null reps)
[10:52:12]   threshold=700 seed=2: baseline_auroc=0.6585 null_auroc_mean=0.6142 p=0.1828 n_cand=852 (9.1s, 1000 null reps)
[10:52:12] building STRING physical-interaction adjacency at score>=900
[10:52:13]   threshold=900: 8706 genes, 89862 directed edge-records in adjacency
[10:52:13]   threshold=900: using null_reps=1000, time_remaining=862s
[10:52:20]   threshold=900 seed=0: baseline_auroc=0.6589 null_auroc_mean=0.6352 p=0.1449 n_cand=443 (7.3s, 1000 null reps)
[10:52:27]   threshold=900 seed=1: baseline_auroc=0.6281 null_auroc_mean=0.6032 p=0.4336 n_cand=424 (6.5s, 1000 null reps)
[10:52:32]   threshold=900 seed=2: baseline_auroc=0.6055 null_auroc_mean=0.5898 p=0.2797 n_cand=449 (5.3s, 1000 null reps)
[10:52:32] total runtime 156.6s
[10:52:32] wrote raw results to raw_results.json
wrote results.json
prediction_outcome=confirmed n_sig=0/3 p_values=[0.17282717282717283, 0.6193806193806194, 0.18281718281718282]
wrote figs/auroc_vs_null.png
wrote figs/topk_jaccard.png